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Carsten Maus, Mathias John, and Adelinde M Uhrmacher (2007)

A Multi-Level and Multi-Formalism Approach for Model Composition in Systems Biology

Poster, Edinburgh (GB), Computational Methods in Systems Biology (CMSB).

The analysis of biological systems by modelling and simulation requires increasingly considering different scales and perspectives. Composing models out of modular units is one step to describe systems at different levels. In addition, the reuse and combination of existing model components can help to create larger models in less time. Different modelling formalisms support individual perspectives on systems under study. Therefore, our approach enriches the composition of models in ml-DEVS (Multi-Level-DEVS) with the ability to include multiple formalisms. As a first step and case study, we designed a wrapper to integrate models in the stochastic pi calculus into ml-DEVS models. We illustrate our approach with an example of the canonical Wnt signalling pathway.

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