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Arne T Bittig, Claudia Matschegewski, Barbara Nebe, and Adelinde M Uhrmacher (2012)

Spatial Simulation of Actin Filament Dynamics on Structured Surfaces

Poster, , Winter Simulation Conference 2012.

We develop a simple model of actin filament growth in bone cells comprising integrin receptors, actin molecules able to form chains and cofilin molecules destroying chains. The model is expressed in the ML-Space modeling language and simulated using a particle-based approach. We find the model to be a promising starting point in reproducing in silico experimentally observed filament growth behavior of bone cells on different surface structures.

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