| |
M. Sc. Carolin Mahler
PhD
Neurobiological Laboratory, Department of Neurology
University of Rostock
|
| Office address |
Gehlsheimerstr. 20
Rostock
|
|
|
| Contact |
Phone: +49 (0)381 494 9771
Carolin dot Mahler@med dot uni-rostock dot de
|
| Information |
Research interests
The Wnt proteins are members of a highly conserved family of signaling
molecules that play a crucial role in development, by controlling
proliferation and differentiation of neural progenitor cells in a
stage-specific and cellular-dependent manner. However, the molecular
events mediating cell differentiation, especially in human neural
progenitor cells, remain poorly understood. We could show that Wnt-3a in
contrast to stabilized beta-catenin increases the neuronal population
in human neuronal progenitor cells (ReNCell VM) which suggests a
beta-catenin independent mechanism. The Wnt pathway is also known to
interact with a plurality number of different signaling pathways e.g.
Notch. Preliminary results reveal a regulation of Notch target genes
HES1 and HES5 by Wnt-3a, but not stabilized beta-catenin Since HES1 and
HES5 are helix-loop-helix (HLH) transcription factors, who can regulate
the fate of neural stem cells, this cross-talk between Wnt and Notch and
its impact on neuronal differentiation of human NPCs will be
investigated further.
CV
2010- Doktorarbeit am Albrecht Kossel Institut, Universität Rostock
2008-2009 (Master-) Biologie Studium an der TU Braunschweig
2005-2008 (Bachelor-) Biologie Studium an der TU Braunschweig
2002-2005 Abitur
|
|
Forgot your password?
