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Svetoslav Nikolow, Bulgaria (in cooperation with WELISA)
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Yann Le Franc, NL
| What | Invited talk |
|---|---|
| When |
2010-05-25 from 17:30 to 19:00 |
| Where | Lecture Hall II, Dept. of Chemistry, Albert-Einsteinstr. 3a |
| Contact Email | lars.schwabe@uni-rostock.de |
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Multiple firing states and nociceptive information processing in the dorsal horn network
Abstract
Deep Dorsal Horn relay Neurons (dDHNs) of the spinal cord are known to
exhibit multiple firing patterns under the control of local metabotropic
neuro-modulations: tonic firing, plateau potential and spontaneous
oscillations.
This work investigates the role of interactions between voltage-gated
channels on the expression of these different firing patterns and then
correlates them to their functional role in sensory information
processing. Using a modeling approach, we found a general mechanism for
the firing switch based on the balance between the inward and outward
currents. This finding allows us to extend the regulation of the firing
switch to other neuromodulators and to network effect like inhibition.
Further exploration revealed the existence of a new firing mode, called
accelerating mode, at the edge of the transition between the tonic and
the plateau mode. We found that this particular mode corresponds to an
optimal information transfer state. This work opens new perspective
about pain information processing in the spinal cord.
First Prize at the Second International Biomodellling Competition Dagstuhl 2011