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Svetoslav Nikolow, Bulgaria (in cooperation with WELISA)
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Axel Kowald, Bochum, GER
| What | Invited talk |
|---|---|
| When |
2008-11-27 from 13:15 to 15:00 |
| Where | R 11, Library, Albert-Einstein-Str.6 |
| Contact Name | Dr. Axel Kowald |
| Contact Phone | +49 231 9742 6321 |
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Defektive mitochondria, oxidative stress and the aging process
Dr. habil. Axel Kowald
Ruhr University Bochum
Medical Proteom Center
Universitaetsstr 150
44801 Bochum, Germany
Aging is a complex biological phenomenon that practically affects all multicellular eukaryotes. It is manifested by an ever increasing mortality risk, which finally leads to the death of the organism. Modern hygiene and medicine has led to an amazing increase in average life expectancy over the last 150 years, but the underlying biochemical mechanisms of the aging process are still poorly understood. Many mechanistic aging theories have been proposed but reactive oxygen species (ROS) and defective mitochondria are currently the most promising. This talk explains where ROS are produced and why they are dangerous. Furthermore the connection between oxygen radicals and mitochondria is highlighted and age related mitochondrial changes are discussed. Finally several ideas and models are presented that address the important question through which mechanisms mitochondrial mutants can accumulate in old cells.
First Prize at the Second International Biomodellling Competition Dagstuhl 2011