Forgot your password?
Svetoslav Nikolow, Bulgaria (in cooperation with WELISA)
Document Actions
Koichi Takahashi, Berkeley, USA
| What | Invited talk |
|---|---|
| When |
2008-07-11 from 14:00 to 15:30 |
| Where | R 11, University Library, Albert-Einstein-Str.6 |
| Contact Name | Koichi Takahashi |
| Contact Email | ktakahashi@molsci.org |
| Add event to calendar |
vCal
iCal
|
The E-Cell Project and Challenges in Computational Systems Biology
The Molecular Sciences Institute,
2168 Shattuck Avenue, Berkeley, CA 94704
and
Institute for Advanced Biosciences,
Keio University, Fujisawa, 252-8520, Japan
Abstract:
Summarizing
our experience in launching and running the E-Cell Project over the past ten
years,
I will
discuss some of major challenges we believe we will face in the next ten years
of cell and
systems
biological simulation, including the following two; (1) Undeniably the last ten
years of
computational
systems biology has been (re)discovery of the biggest bottleneck in biochemical
modeling;
the lack of high-throughput and reliable means of obtaining reaction rate
coefficients.
Computational
aids in determination of reaction rate coefficients will be one area in which
fruitful
interactions between molecular biology, biophysical chemistry, and
supercomputing
are
highly expected. (2) Macromolecular crowding is ubiquitous and found in all
types of
cellular
organisms on the earth, which can, when coupled with localization and
diffusion, alter
biochemical
dynamics, change equilibrium points, slow down and change the manner how
big
molecules diffuse, and amplify intrinsic noise. It is also a suspected
physico-chemical
factor
behind the emergence of eukaryotic organisms. Development of formal treatment
and
computational
methods for crowded intracellular media will be some of the most important
tasks left for computational biologists
First Prize at the Second International Biomodellling Competition Dagstuhl 2011