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Svetoslav Nikolow, Bulgaria (in cooperation with WELISA)
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Monika Heiner, Cottbus, GER
| What | Invited talk |
|---|---|
| When |
2007-11-05 from 11:00 to 12:30 |
| Where | Seminarraum Biologie 204, Albert-Einstein-Str.3 |
| Contact Name | Prof. Monika Heiner |
| Contact Email | monika.heiner@gmx.de |
| Contact Phone | +49 (0)355 317888 |
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Modularization of Biochemical Networks by T-invariants
Biochemical networks - as metabolic networks, signal transduction
networks, or gene regulatory networks - are by their very nature
bipartite graphs with nodes representing biochemical entities or
reactions. Thus, biochemically interpreted Petri nets are an intuitive
approach in systems biology, allowing at the same time to reuse
established Petri net analysis techniques for validation of biochemical
network knowledge and model-based experiment design.
Among these techniques, T-invariants (closely related concepts are
elementary modes and extreme pathways) have been proven especially
useful for various purposes. In this talk we demonstrate how
T-invariants suggest a modularization of a given network into its
smallest functional units.
These functional units allow the coarsening of the network, which
contributes to a better understanding of complex networks by
highlighting the inherent structure of the set of all T-invariants. The
proposed method is motivated by a couple of biochemical network examples.
Prof. Monika Heiner
BTU Cottbus
First Prize at the Second International Biomodellling Competition Dagstuhl 2011