Monika Heiner, Cottbus, GER
from 11:00 to 12:30
|Where||Seminarraum Biologie 204, Albert-Einstein-Str.3|
|Contact Name||Prof. Monika Heiner|
|Contact Phone||+49 (0)355 317888|
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Modularization of Biochemical Networks by T-invariants
Biochemical networks - as metabolic networks, signal transduction networks, or gene regulatory networks - are by their very nature bipartite graphs with nodes representing biochemical entities or reactions. Thus, biochemically interpreted Petri nets are an intuitive approach in systems biology, allowing at the same time to reuse established Petri net analysis techniques for validation of biochemical network knowledge and model-based experiment design.
Among these techniques, T-invariants (closely related concepts are elementary modes and extreme pathways) have been proven especially useful for various purposes. In this talk we demonstrate how T-invariants suggest a modularization of a given network into its smallest functional units.
These functional units allow the coarsening of the network, which contributes to a better understanding of complex networks by highlighting the inherent structure of the set of all T-invariants. The proposed method is motivated by a couple of biochemical network examples.
Prof. Monika Heiner