Aim of this project is the clarification of the function of the canonical Wnt/Fz/Dsh/GSK-3ß/ß- Catenin- signalling pathways for the differentiation of human neural progenitor cells. The analyses will help to understand to which extend this signalling pathway induces or fastens the differentiation. The necessity of the pathway for differentiation as well as possible interactions with non-canonical Wnt-pathways will be tested by the selective perturbation on different stages. Data for the mathematical modelling of the pathway will be based on gene expression and proteome analysis. The identification of new target genes of the canonical pathway is anticipated, which will of high importance for the neuronal differentiation.