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Venkata Ajay Narendra Talabattula

last modified 2010-11-17 13:19

M.Sc. Ajay N. V. Talabattula
PhD
Neurobiological Laboratory, Department of Neurology
University of Rostock
Office address
Gehlsheimer Str. 20
Rostock/Germany
Contact
Phone: +49 (0)381 494 9771
narendra@med dot uni-rostock dot de
Information

Research interests

  • The aim of this project is to investigate the effects of Wnt/calcium-pathway on the differentiation of ReNcell VM cells by physiological state or upon the stimulation with purified Wnt proteins or in down-regulation of endogenous Wnts by specific small interfering RNA (siRNA) transfection. The quantities of cellular free calcium concentration, calcium sensitive enzymes like protein kinase C (PKC), calcium-calmodulin dependent kinase II (CamKII), calcineurin (CaCN) and other proteins, e.g., nuclear factor of activated T cells (NFAT) will be analysed during cell differentiation at different time points by real-time PCR and quantitative Western blot. The quantitatively collected data will be used to create an integrative model of Wnt signal pathway for neural progenitor cells.


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