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M. Sc. Carolin Mahler

last modified 2010-11-17 12:01

M. Sc. Carolin Mahler
PhD
Neurobiological Laboratory, Department of Neurology
University of Rostock
Office address
Gehlsheimerstr. 20
Rostock
Contact
Phone: +49 (0)381 494 9771
Carolin dot Mahler@med dot uni-rostock dot de
Information

Research interests


The Wnt proteins are members of a highly conserved family of signaling molecules that play a crucial role in development, by controlling proliferation and differentiation of neural progenitor cells in a stage-specific and cellular-dependent manner. However, the molecular events mediating cell differentiation, especially in human neural progenitor cells, remain poorly understood. We could show that Wnt-3a in contrast to stabilized beta-catenin increases the neuronal population in human neuronal progenitor cells (ReNCell VM) which suggests a beta-catenin independent mechanism. The Wnt pathway is also known to interact with a plurality number of different signaling pathways e.g. Notch. Preliminary results reveal a regulation of Notch target genes HES1 and HES5 by Wnt-3a, but not stabilized beta-catenin Since HES1 and HES5 are helix-loop-helix (HLH) transcription factors, who can regulate the fate of neural stem cells, this cross-talk between Wnt and Notch and its impact on neuronal differentiation of human NPCs will be investigated further.


CV


2010-         Doktorarbeit am Albrecht Kossel Institut, Universität Rostock
2008-2009 (Master-) Biologie Studium an der TU Braunschweig
2005-2008 (Bachelor-) Biologie Studium an der TU Braunschweig
2002-2005 Abitur

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