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Research Project: FSIII

created by zopeadmin last modified 2010-11-05 11:52

Biological systems as regenerative systems

The central nervous system of mammals can serve as a model for self-organisation and regeneration in informatics, consisting of a population of homogenous, multipotent functional units - stem cells.
Stem cells have the enormous ability to create highly complex, information processing structures by self-organisation and adjusted communication, which are able to sustain their functionality after significant perturbation.
Substantial instruments are thereby intercellular signal substances which permit communication and an instructive self organization of the individual functional units.
Within the ontogenesis as well as in the maintenance of the neural plasticity and the regeneration of the central nervous system signal proteins of the Wnt family play an outstanding role.
Therefore the mechanisms of this high-complex signalling pathways are gathered, described and modelled in a model system. The detailed understanding of the control mechanisms has crucial meaning for cell biological expirations of regularization. Moreover it enables us in foreseeable future to develop and use new substances,  with an appropriate medical-therapeutic value, to the influence the regeneration of the nervous system. Reliable, reproducible and experimental investigations for the modelling of the signal paths and the multi-protein complexes are based on cell lines of neural progenitor cells, which can be kept standardized in long-term cultures. Cell lines with special clinical relevance (from the Mesencephalon) and with a model character for adult regeneration and plasticity (from the Hippocampus) were selected for this research project.
In these cells the role of the canonical and the non-canonical calcium Wnt signalling pathway and their interaction for the neural differentiation of neural progenitor will be analysed. The classical molecular-biological methods concerning the complexity of cell biological regulation ways are insufficient. Intracellular signalling pathways cannot be investigated without a broad bioinformatic technical platform. The analysis of several signalling pathways and their regulation demand special modelling and simulation methods. For gathering new facts about regulation of signalling pathways on the base of highly standardised pathways of cell systems, the design of new methods is absolutely necessary. These should lighten the repeated through run of phases of hypothesis gaining, design of experiments, modelling and simulation.
For a more deeply understanding of the examined complex systems, this iterative process will contribute as well as to the better integration of modelling and simulation in the experimental realisation process.




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